Today’s topic is about a bisexual disease called hypogonadism. This post Hypogonadism Causes-Symptoms Treatment ASB, is full of necessary details you care about.

Hypogonadism: Hypogonadism Causes-Symptoms Treatment ASB

Hypogonadism is a defect of the reproductive system that results in lack of function of the gonads. Either ovaries or testes. It is the breakdown of the gonads. In men its testes and in women its ovaries that fail to be in proper action. The production of a male’s testosterone and a female’s estrogen are inhibited. Growth and sexual development may be affected if the attack is before the developmental phase (puberty). After puberty, there may occur sexual difficulties, fertility reduction and absence of menstruation.

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Male hypogonadism

There are hormone that plays a principal role in masculin growth. They contribute to testosterone or enough sperm (even both) development during puberty. If the body doesn’t produce enough of this substances, in this condition it is a male hypogonadism. It can result from a primary testicular disorder or occur secondary to hypothalamic-pituitary dysfunction. Hypergonadotropic hypogonadism is also known as primary hypogonadism and is the most frequent form hypogonadism found in adult men.

Causes of Hypogonadism

  • Auto-immune disorders: addison’s disease and hypoparathyroidism.
  • Genetic disorders: turner syndrome and klinefelter syndrome
  • Severe infections ,especially mumps involving your testicules
  • Liver and kidney diseases
  • Undescended testes.

Male hypogonadism means the testicles don’t produce enough of the male sex hormone testosterone. There are two basic types of hypogonadism:

  • Primary.

This type of hypogonadism also known as primary testicular failure originates from a problem in the testicles.

  • Secondary.

This type of hypogonadism indicates a problem in the hypothalamus or the pituitary gland parts of the brain that signal the testicles to produce testosterone. The hypothalamus produces gonadotropin-releasing hormone, which signals the pituitary gland to make follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Luteinizing hormone then signals the testes to produce testosterone.

Other type of hypogonadism can be caused by an inherited (congenital). Trait or something that happens later in life (acquired), such as an injury or an infection. At times, primary and secondary hypogonadism occur together.

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Primary hypogonadism:

Common causes of primary hypogonadism include:

  • Klinefelter syndrome.

This condition results from a congenital abnormality of the sex chromosomes, X and Y. A male normally has one X and one Y chromosome. In Klinefelter syndrome, two or more X chromosomes are present in addition to one Y chromosome. The Y chromosome contains the genetic material that determines the sex of a child and related development. The extra X chromosome that occurs in Klinefelter syndrome causes abnormal development of the testicles. This in turn results in underproduction of testosterone.

  • Undescended testicles.

Before birth, the testicles develop inside the abdomen and normally move down into their permanent place in the scrotum. Sometimes one or both of the testicles aren’t descended at birth. This condition often corrects itself within the first few years of life without treatment. If not corrected in early childhood, it can lead to malfunction of the testicles. And then reduced production of testosterone.

  • Mumps orchitis.

A mumps infection involving the testicles that occurs during adolescence or adulthood can damage the testicles, affecting the function of the testicles and testosterone production.

  • Hemochromatosis.

Too much iron in the blood can cause testicular failure or pituitary gland dysfunction, affecting testosterone production.

  • Injury to the testicles.

Because they’re outside the abdomen, the testicles are prone to injury. Damage to normally developed testicles can cause hypogonadism. Damage to one testicle might not impair total testosterone production.

  • Cancer treatment.

Chemotherapy or radiation therapy for the treatment of cancer can interfere with testosterone and sperm production. The effects of both treatments often are temporary, but permanent infertility may occur. Although many men regain their fertility within a few months after treatment, preserving sperm before starting cancer therapy is an option for men.

Secondary hypogonadism

In secondary hypogonadism, the testicles are normal but don’t function properly due to a problem with the pituitary or hypothalamus. A number of conditions can cause secondary hypogonadism, these include:

    • Kallmann’s syndrome.

This is an abnormal development of the area of the brain that controls the secretion of pituitary hormones (hypothalamus). This abnormality can also affect the ability to smell (anosmia) and cause red-green color blindness.

    • Pituitary disorders.

An abnormality in the pituitary gland can impair the release of hormones from the pituitary gland to the testicles, affecting normal testosterone production. A pituitary tumor or other type of brain tumor located near the pituitary gland may cause testosterone or other hormone deficiencies. Also, treatment for a brain tumor, such as surgery or radiation therapy, can affect the pituitary gland and cause hypogonadism.

    • Inflammatory disease.

Certain inflammatory diseases, such as sarcoidosis, histiocytosis and tuberculosis, involve the hypothalamus and pituitary gland and can affect testosterone production.

    • HIV/AIDS.

HIV/AIDS can cause low levels of testosterone by affecting the hypothalamus, the pituitary and the testes.

    • Medications.

The use of certain drugs, such as opiate pain medications and some hormones, can affect testosterone production.

    • Obesity.

Being significantly overweight at any age might be linked to hypogonadism.

    • Normal aging.

As men age, there’s a slow, progressive decrease in testosterone production. The rate varies greatly.

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Symptoms Hypogonadism Causes-Symptoms Treatment ASB

Hypogonadism can begin during fetal development, before puberty or during adulthood. Signs and symptoms depend on when the condition develops.

Fetal development

If the body doesn’t produce enough testosterone during fetal development, the result may be impaired growth of the external sex organs. Depending on when hypogonadism develops and how much testosterone is present. A child who is genetically male may be born with:

  • Female genitals
  • Genitals that are neither clearly male nor clearly female (ambiguous genitals)
  • Underdeveloped male genitals


Male hypogonadism can delay puberty or cause incomplete or lack of normal development. It can hamper:

Complications Hypogonadism Causes-Symptoms Treatment ASB

The complications of untreated hypogonadism differ depending on when it develops during fetal development, puberty or adulthood.

Complications might include:

  • Abnormal genitalia
  • Enlarged male breasts (gynecomastia)
  • Infertility
  • Erectile dysfunction
  • Osteoporosis
  • Poor self-image
  • Excessive growth of the arms and legs in relation to the trunk of the body
  • Development of breast tissue (gynecomastia)


Effective testosterone replacement in men with hypogonadism has been showed to maintain secondary sexual characteristics. Increase libido, muscle strength, fat-free mass, and bone density.

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